iSQUARE is a 31-storey high shopping mall located at 63 Nathan Road, Tsim Sha Tsui, Kowloon, Hong Kong, on the former site of the Hyatt Regency Hotel. It was developed by the Associated International Hotels Ltd.

iSQUARE was designed by architecture firms Rocco Design Ltd and Benoy. It has an approximately 600,000 square feet (56,000 square metres) retail space area for shopping, entertainment and iTOWER. Situated at the intersection of Nathan Road and Peking Road, iSQUARE is the first one-stop shopping and entertainment complex linked to Tsim Sha Tsui MTR station. The retail space area is located from the basement to level 8. On level 7, there are five cinemas which provide 1,000 seats. iTOWER has 20 storeys and there are several restaurants inside, bringing customers not only a nosh, but also a view of the Victoria Harbour. One of the levels is occupied by Associated International Hotels Ltd.